Best Infertility Treatments in 2025: IUI, IVF and New Advanced Options

Assisted Reproductive Technologies for Infertility

If you have been trying to conceive for over a year despite regular unprotected intercourse, you may be dealing with infertility. It can bring emotional stress and societal judgments, especially for women. In India, women have faced criticism for years for not being able to bear children. What often goes unnoticed is that infertility can affect both genders. Male infertility accounts for 30% of cases and makes up nearly 50% of all infertility diagnoses when combined with female factors.

With changing lifestyles and rising health issues, infertility in both men and women is increasing. The good news is that assisted reproductive infertility treatments such as IVF, IUI and ICSI are helping more families than ever and are becoming widely accepted.

Common Reasons For Infertility

Many factors can contribute to infertility, and sometimes the reason remains unknown or undiagnosed. Undergoing diagnostic tests is a crucial first step to identifying the possible cause and choosing the most suitable treatment.

Female Infertility

In women, infertility is mostly a result of hormonal disturbances, but several other factors may contribute:

• Hormonal Imbalance: Hormonal imbalances can interfere with the release of a healthy egg, which is necessary for ovulation. The most common hormonal disorder affecting women is PCOD/PCOS, though issues involving the pituitary gland or hypothalamus can also affect hormone regulation.
• Anatomical Blockages: Blockages in the fallopian tubes can prevent sperm from reaching the egg and prevent fertilisation. These blockages may develop from untreated sexually transmitted infections, surgical injuries or postpartum infections.
• Uterine Disorders: Inflammatory conditions such as endometriosis or fibroids can interfere with implantation and conception.
• Infections: Sexually transmitted diseases like gonorrhoea and chlamydia can lead to pelvic inflammatory disease affecting the uterus, fallopian tubes or both, increasing the risk of ectopic pregnancies.
• Immune System Disorders: Abnormal immune responses may interfere with fertilisation, implantation or early pregnancy.

Male Infertility

In men, infertility often stems from issues affecting sperm production, transport or quality:

• Obstructions or Blockages: Blockages in the seminal vesicles or ejaculatory ducts can reduce sperm count or cause difficulty ejaculating.
• Hormonal Disorders: Conditions linked to testicular cancer or pituitary gland dysfunction can impair sperm production.
• Varicocele: Enlarged veins around the testes may reduce sperm quality; this is often treatable with surgery.
• Abnormal Sperm Shape or Motility: Irregular sperm morphology or reduced motility can hinder successful fertilisation.
• Sexually Transmitted Infections: Untreated infections can affect sperm production, function or transport.

New Advances in IVF

Several technologies have made the IVF process a little less stressful by ensuring precision and accuracy, boosting success rates for couples undergoing infertility treatment, such as:

Microfluidics Integration with IVF

Microfluidics involves the controlled movement and manipulation of fluid. This process has been used with IVF to isolate sperm from semen. A sperm isolating microfluidic device is used to select sperm with better motility and healthier morphology. It can also be used to identify healthier eggs, improving the chances of fertilisation and embryo development.

Preimplantation Genetic Testing (PGT)

PGT is an additional IVF procedure that helps with the detection of parental genetic mutations that can be inherited. It can also detect chromosomal defects, including trisomies and monosomies. This allows clinicians to transfer the healthiest embryo and reduce the risk of genetic disease.

In Vitro Maturation (IVM)

This process enables physicians to collect immature eggs and mature them in the laboratory. IVM reduces the need for ovarian induction.

The advantages of IVM include:

• reduced stress,
• lower medication requirement and cost,
• lowers the risk of OHSS (Ovarian Hyperstimulation Syndrome) and
• a better option for polycystic ovaries.

AI in Embryo Selection

Deep learning algorithms help in analysing images, metabolic factors and patient profiles to predict and select embryos with the highest chances of implantation. This reduces the chances of human error and adds another layer of precision to the treatment.

Co-Treatment with Gonadotropins

The gonadotropin stimulation, along with the oral medication letrozole during IVF cycles, has shown benefit, especially in women with breast cancer undergoing fertility preservation treatment. This combination helps with a reduction in blood oestrogen levels.

Time-Lapse Embryo Imaging

Time-lapse monitoring systems capture pictures of the embryo at intervals ranging from 5-20 minutes. Compared to PGT, this technique is a bit expensive, but it is non-invasive and prevents the risk of damage to the embryo.

The developmental patterns provided by time-lapse techniques help with the identification of the chromosomal status of the embryo, which means picking up embryos with less chance of chromosomal abnormalities.

Conclusion

There is no single best infertility treatment for all. The right option depends on diagnosis, age, medical history, budget and location. What’s clear is that today’s infertility treatments are more advanced, accurate and patient-friendly than ever.

Among them, IVF remains a leading choice in 2025, strengthened by progress in genetic testing, microfluidics, AI-supported embryo selection and time-lapse monitoring. A combination of thorough diagnostics and evidence-backed interventions offers a smoother and more reassuring path to parenthood, helping individuals and couples move forward with clarity and confidence.