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Adenomyosis vs Fibroids: Differences, Symptoms & Treatment Explained

Dr. Dhruvitha Koduri
Reviewed by Dr. Dhruvitha Koduri ,
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This information has been reviewed and approved by an experienced fertility specialist at Indira IVF to provide accurate and up-to-date guidance for our readers.

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Last updated: October 13, 2025

Overview

Adenomyosis and fibroids are two different, yet common, gynaecological issues that affect the uterus, and many women experience them along with heavy bleeding, pain, or discomfort. Although they may share similar symptoms, they are quite different and are treated differently.

What is Adenomyosis?

Adenomyosis is a condition in which endometrial tissue (the lining of the uterus) grows into the muscular wall of the uterus (the myometrium). This abnormal growth can thicken the walls of the uterus, which can lead to pain, heavy menstrual bleeding, and bloating.

Key facts about adenomyosis:

  • There may be a noticeable enlargement or pain in your uterus.
  • Symptoms may include heavy menstrual bleeding, severe cramps, & bloating.
  • It is most common in women aged between 35 and 50 years.

Adenomyosis is not life-threatening, but it can severely impact a woman’s quality of life, especially during her menstrual period. Although the cause of adenomyosis is unknown, the condition usually disappears after menopause.

Also Read : How to treat an irregular period?

What are Fibroids?

https://www.indiraivf.com/infertility-problems/irregular-periods

Uterine fibroids may be classified based on their location/origin and attachment mode. Specific types of uterine fibroids include:

  • Submucosal fibroids : Fibroids that grow under the inner lining of your uterus.
  • Intramural fibroids : These are found embedded in the muscular wall of your uterus. These are the most common types of fibroids.
  • Subserosal fibroids : This type of fibroid grows under the lining of the outer surface of your uterus. They may get very large and can grow into your pelvis.

Key facts about fibroids:

  • Fibroid size can range from very small to very large.
  • Common symptoms include heavy periods, pelvic pain, increased frequency of urination, constipation, and abdominal distension.
  • These procedures are strongly related to hormonal disorders and genetic susceptibility.

Adenomyosis vs Fibroids: Key Differences

Adenomyosis and fibroids may be quite similar at first sight, as they both result in heavy bleeding, pain in the pelvis, and a swollen uterus. But they differ pretty much in terms of their nature. Adenomyosis is a condition in which the inner lining of the uterus (endometrium) penetrates through the muscle layer (myometrium), and fibroids are benign and non-malignant masses consisting of muscle and connective tissue. This variation in aetiology also affects their behaviour, their diagnosis, and treatment regimens.

Women with adenomyosis frequently complain of severe pain and heaviness of periods; women with fibroids may also complain of pressure symptoms (frequent urination or constipation). Importantly, adenomyosis tends to diffuse throughout the uterine wall, making it harder to surgically remove, while fibroids are well-defined growths that can be targeted individually.

Here is a side-by-side comparison:

Aspect Adenomyosis Fibroids
Nature Endometrial tissue grows into the uterine muscle Non-cancerous tumours made of muscle and tissue
Location Within the uterine wall (diffuse) In or around the uterus (cavity, wall, or surface)
Cause Linked to hormones, prior uterine surgery, and high oestrogen Hormonal imbalance, genetics, and family history
Symptoms> Heavy bleeding, severe cramps, bloating, and an enlarged uterus Heavy bleeding, pelvic pressure, frequent urination, and constipation
Diagnosis MRI and ultrasound; often harder to confirm Ultrasound, MRI, hysteroscopy, pelvic exam
Treatment Pain relief, hormonal therapy, hysterectomy (severe cases) Medications, non-invasive procedures, myomectomy, hysterectomy

Adenomyosis vs Fibroids Causes and Risk Factors

Although the exact cause of fibroids and adenomyosis is unknown, there are several variables that increase the risk of acquiring them. Although the reasons for fibroids and adenomyosis are distinct, it is clear that both conditions are influenced by hormonal and genetic factors. Additionally, being able to distinguish between fibroids and adenomyosis can aid in early identification and treatment promotion.

Adenomyosis :

  • A history of prior uterine surgery, such as fibroid excision or C-section.
  • A history of extended exposure to elevated amounts of oestrogen.
  • Women over the age of 35 are more likely to experience it.

Fibroids :

  • Genetic factors show up to play an important role.
  • Obesity increases the imbalance of hormones.
  • History of fibroids in the family
  • Elevated estrogen provides a stimulus for fibroid growth.

Although both fibroids and adenomyosis are hormone-dependent, oestrogen levels have a particularly significant impact.

Also Read : How does Chocolate Cyst Affect Female Fertility?

Adenomyosis vs Fibroids Diagnosis

Since adenomyosis and fibroids often have overlapping symptoms, including heavy bleeding and pelvic pain, accurate diagnosis is important in determining which treatment will be appropriate. Most doctors will start by conducting an extensive physical examination, studying the patient’s history, and then move on to imaging studies.

Fibroids are relatively easy to detect, as they create solid, distinct masses. Adenomyosis, on the other hand, tends to diffuse in the uterine muscle. Therefore, without advanced imaging, it is more difficult to locate adenomyosis.

Common diagnostic methods include:

  • Pelvic exam : Helps identify uterine enlargement or tenderness.
  • Ultrasound : First imaging to identify fibroids and/or uterine changes.
  • MRI : Provides detailed images to distinguish adenomyosis from fibroids.
  • Hysteroscopy or biopsy : Rarely used, but possibly useful for confirming diagnosis in specific cases.

Women who had more precise diagnoses were able to obtain tailored therapy that improved their chances of controlling their symptoms and achieving infertility.

Adenomyosis vs Fibroids Treatment Options

Adenomyosis Treatment

  • Pain relief : If pain is severe, doctors suggest anti-inflammatory medications for pain control.
  • Hormonal therapy : Combined estrogen and progestin birth control pills or contraceptive patches, or rings that contain hormones, may decrease the amount of heavy bleeding and pelvic pain associated with adenomyosis.
  • Hysterectomy : When the pain is severe and no other treatments work, the doctor may suggest surgery to remove the uterus.

Fibroid Treatment Medications:

Uterine fibroid treatment tends to use medications designed to help stabilise hormones controlling the menstrual cycle and to alleviate symptoms such as heavy bleeding and pelvic pressure.

Non-invasive procedures:

  • Uterine artery embolisation (UAE) : This treatment stops the blood supply to the fibroid, thereby making it wither out and become inactive.
  • MRI-guided HIFU (High-Intensity Focused Ultrasound) : This procedure involves the destruction of the fibroid using sound waves, whereby the fibroid shrivels without surgical intervention.

Surgical options:

  • Myomectomy : A myomectomy is when a surgeon removes the fibroids.
  • Hysterectomy : This method is the removal of the uterus and is the only proven permanent procedure for uterine fibroids.

The choice of treatment depends on symptom age, severity, fertility goals, and overall health.

Which Condition is More Serious?

Adenomyosis and fibroids are non-cancerous and not life-threatening conditions. However, their impact ranges from non-serious to very serious, and varies from woman to woman. There are cases where women experience mild symptoms which they can bear, and there are cases where individuals experience prolonged severe bleeding, pain and infertility problems.

The impact of either condition will depend on:

  • Severity of symptoms.
  • Fertility goals (adenomyosis and fibroids can affect implantation and pregnancy outcomes).
  • Response to treatment.

To choose the best course of action for a given situation, a gynaecologist's advice is crucial.

Conclusion

Despite the fact that they both affect the uterus, fibroids and adenomyosis have different traits, causes and treatment. Fibroids are benign tumours in the uterus, and adenomyosis is a condition whereby endometrial tissue extends into the uterine wall. Pelvic pain and heavy bleeding can be associated with both conditions, yet different approaches are used to treat them.

If you are experiencing ongoing menstrual pain or heavy bleeding, you should see a gynaecologist to get the right diagnosis and treatment. Early medical care may assist you in controlling symptoms better and enhancing your quality of living.

Also Read : What can you expect after IVF treatment?

Common Questions Asked

Can fibroids be misdiagnosed as adenomyosis?

 

Yes. Due to the similarities in symptoms, imaging tests like the MRI are significant in distinguishing between the two conditions.

How to differentiate adenomyosis and leiomyoma?

 

Adenomyosis involves tissue invading the uterine wall itself, while leiomyomas (fibroids) are solid tumours with or without uterine cavity involvement.

Can fibroids cause IVF failure?

 

Yes, particularly in cases of uterine fibroid deformation. The chance of miscarriage increases if an implant is not done correctly.

How can I shrink my fibroids before IVF?

 

Management is possible through medication, uterine artery embolisation, minimally invasive or surgical treatments. Your doctor will recommend a less dangerous option depending on your reproductive goals.

Is adenomyosis linked to infertility?

 

Adenomyosis can affect implantation, and since it can do that, it can be really difficult for a woman to conceive. Many women with adenomyosis have successfully achieved pregnancy.

How to improve implantation with adenomyosis?

 

There may be options that could include hormonal treatments and assisted reproductive treatments. For women's specific cases, having assistance from a reproductive physician/specialist is the best approach.

Can I have successful IVF with adenomyosis?

 

Yes, with the appropriate treatment and under appropriate medical supervision, many women with adenomyosis have had successful IVF outcomes.

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