Author Name: Dr. Arnab Barma Mentor Name: Dr. Amol Naik on April 08, 2020

What is assisted hatching?

Assisted hatching is a laboratory micromanipulation technique carried out before the embryos are replaced in the uterus following an IVF or ICSI cycle that helps the embryo to hatch from the zona.

In natural conception mixing of eggs and sperm occur within a women’s body whereas in IVF it occurs in a Laboratory and hence the name Test Tube Baby. When a sperm penetrates the egg, the egg is fertilised. During IVF, the fertilized eggs are monitored for 3 to 6 days as they divide and develop into embryos. For the first 5 to 7 days of development, the embryo is surrounded and protected by an outer shell called the zona pellucid. Normally when the embryo reaches the uterus, this zona partially dissolves and the embryo hatches out and implants in the endometrial lining of the uterus. In some patients the zone becomes so hard that it becomes difficult for the embryo to hatch and implant.

Sometimes, the doctor may ask the embryologist to make a small “Hole” in the outer shell of the embryo right before it is placed into the woman’s uterus. The assisted hatching might help the embryo expand, implant into the uterine wall, and finally lead to a pregnancy. The reason is to place the best embryo into the woman’s womb and helping her become pregnant or it can be frozen for future use.

Who all are the candidates for Assisted Hatching?

• Woman is aged 35 years or older
• Couples having failed previous IVF cycles
• Woman having high FSH levels during follicular phase
• Frozen embryo replacements
• Thickened zona noted by embryologists
• Embryos not developing well as expected.

What are the risks associated with assisted hatching?

There is a slight increased risk for identical

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