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IVF and Pregnancy at 45: What You Need to Know

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Last updated: October 31, 2025

Overview

It is tough to get pregnant at 45. Women at 45 face many challenges when trying to get pregnant, but it is possible. Many advancements have taken place in assisted reproductive techniques, such as IVF, that have made it possible for women to enjoy motherhood at 45. Natural fertility starts decreasing with age, but new techniques such as IVF, donor eggs, frozen eggs, or embryos have opened a ray of hope for women who wish to enjoy motherhood at the age of 45. In this article, we will learn about the success rate of IVF at 45, the risks and challenges involved, and how to enhance the chances of pregnancy with IVF at 45.

Can You Get Pregnant at 45 Naturally?

It is difficult for a woman to get pregnant at 45 naturally because fertility starts declining at this age. The quality and quantity of eggs decrease with age. Natural conception is possible in some women, but it occurs rarely. Only a few viable eggs are produced at this age. Hormonal changes also take place, due to which ovulation also becomes irregular. This reduces the chances of naturally getting pregnant at 45. Women have to face several challenges to conceive naturally at 45, which include the following:

  • Only a few healthy eggs are available in women at 45
  • The risk of chromosomal abnormalities in eggs increases with age
  • The risk of miscarriage or unsuccessful implantation increases
  • Ovulation time gets irregular due to hormonal imbalance and irregular periods

The chance of getting pregnant naturally at 45 is only 1%. Women can consult with a fertility expert, maintain good health, manage stress levels, and explore new and safe methods for conception.

IVF as an Option at 45

IVF (In vitro fertilisation) is a process in which a fertility expert uses fertility drugs to stimulate the ovaries to produce healthy eggs, which are then retrieved and fertilised with sperm in a lab. The developed embryo is then transferred into the uterus. It is a wonderful option to get pregnant at 45.

IVF process details:

The doctor recommends hormonal tests and ultrasounds for both partners to assess general health, ovarian reserve, and sperm health.

  • Medications, including oral medicines and injections, are given to stimulate the ovaries to produce multiple eggs.
  • Mature eggs are retrieved from the ovaries.
  • Eggs are kept with sperm under controlled conditions for fertilisation in a lab until embryos are formed.
  • One or more healthy embryos are placed into the uterus for successful implantation under anaesthesia. A woman may experience some discomfort for a few days.

If egg and sperm quality are poor, fertility experts recommend using donor eggs or sperm to achieve success. A woman must consider physical, emotional, and financial factors before starting IVF treatment at 45.

Success Rates of IVF at 45

The success rate of IVF at 45 depends on many factors, such as:

  • A woman uses her own eggs or donor eggs
  • Overall health of a woman and hormonal balance
  • Sperm quality and quantity
  • Embryo health
  • Uterine receptivity and endometrial thickness
  • Other fertility problems, such as PCOD, endometriosis, or fibroids.
  • Ovulation timing

The success rate is low when a woman uses her own eggs because egg quality and quantity decrease with age. There is also a risk of increased chromosomal abnormalities. The success rate is high if a woman uses donor eggs from a younger woman. Fertility experts use advanced techniques such as preimplantation genetic testing (PGT) and embryo freezing to enhance the chances of a healthy pregnancy when a woman uses her own eggs.

Risks and Considerations of Pregnancy at 45

Many risks and complications are involved for women who want to get pregnant at 45 with IVF. It involves both maternal and fetal risks; therefore, it should be done under an expert fertility doctor. Risks and complications occur due to age-related changes, though many women deliver healthy babies as well.

Common risks and complications are:

  • Preterm birth or low birth weight
  • Gestational diabetes and high blood pressure
  • Preeclampsia or placental complications
  • A high risk of chromosomal disorders, such as Down syndrome
  • Multiple pregnancies
  • Risk of cesarean delivery

A woman must make some considerations before trying to get pregnant at 45:

  • Regular health check-ups and prenatal monitoring are necessary
  • Avoid stress and meet a counsellor to seek emotional and psychological help
  • Eat a balanced and nutritious diet
  • Avoid drinking alcohol, smoking, and excess intake of caffeine.

Many women can successfully achieve a healthy pregnancy at 45 by making lifestyle changes under the guidance of an expert fertility doctor.

Tips to Increase Chances of Pregnancy at 45

The chances of pregnancy at 45 can be increased by using the right approach. Some tips to increase the chances of pregnancy at 45 are:

  • The first step is to consult with an experienced fertility expert who can evaluate your case and recommend the right treatment.
  • The doctor will give fertility medications and supplements to start the process. Take your medications regularly. Folic acid, zinc, and vitamin D are useful for the formation of healthy eggs.
  • The fertility expert will monitor ovulation and uterine health for egg retrieval and embryo implantation.
  • Regular exercise is essential to maintain a healthy weight. Simple exercises, such as walking, can help maintain a healthy weight.
  • Eat a well-balanced, healthy diet that includes lean proteins, antioxidants, and whole grains to support hormonal balance and improve egg quality.
  • Reduce stress by practising yoga, breathing exercises, and meditation. Meet a counsellor to reduce anxiety and stress.
  • Stay positive and happy throughout treatment for better outcomes.

What are the Fertility Treatment Options for Women at 45 With Low Ovarian Reserve?

A low ovarian reserve means a poor quality and quantity of eggs. A low ovarian reserve means a risk of improper cell division and embryo development. It may cause faulty splitting of the genetic material. It can also cause abnormal embryo development and failed implantation during an IVF treatment. This may happen if a woman tries to conceive naturally or with IVF treatment.

IVF with frozen eggs

IVF with frozen eggs is also an option for women at 45 with low ovarian reserve. A fertility doctor uses frozen eggs in this process. Frozen eggs can be obtained from a donor or the patient. Some women freeze their eggs at an early age to use them later. The eggs are retrieved from storage banks and thawed before the general IVF process is carried out.

IVF with donated eggs

Another option is using donor eggs during IVF treatment. Donor eggs can be chosen from a young woman to achieve a successful pregnancy.

Therefore, it is recommended that a woman at 45 with a low ovarian reserve consider using frozen or donor eggs from a young woman. Consult with a fertility expert to get the best treatment option to achieve pregnancy at 45.

Conclusion

Pregnancy at 45 can be challenging, but it is not impossible. Some women may still conceive naturally with the right guidance and personalised care. Women who do not achieve a natural pregnancy at 45 can go for advanced treatments like IVF. You must consult with a fertility expert to evaluate your health and fertility status.

Common Questions Asked

Can women get pregnant naturally at 40?

 

Yes, a woman can get pregnant naturally at 40, but fertility reduces with age. Egg quality and quantity decrease, making it challenging to conceive naturally.

What are the chances of IVF success at 45?

 

The chance of IVF success is less if a woman uses her own eggs as compared to using donor eggs. The chances of IVF success at 45 depend on whether a woman uses her own eggs or donor eggs.

Should donor eggs be considered for IVF at 45?

 

Yes, fertility experts recommend using donor eggs for IVF at 45 because ovarian reserve is reduced. This can cause an unsuccessful pregnancy or miscarriage.

What are the risks of pregnancy at 45?

 

Pregnancy risks at 45 are quite high and include gestational diabetes, high blood pressure, chromosomal abnormalities, and cesarean or preterm delivery.

How can lifestyle changes improve the chances of pregnancy at 45?

 

Lifestyle changes such as maintaining a healthy weight, eating a balanced diet, engaging in regular exercise, managing stress, avoiding alcohol, smoking, and processed foods, and getting proper sleep can help improve the chances of pregnancy at 45.

Is IVF painful for women over 45?

 

IVF is not a painful process because egg retrieval and embryo implantation are done under anaesthesia. Thus, it is a safe process for women over 45.

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