Diabetes is a metabolic disorder that affects the function of several organ systems, including the reproductive system. Diabetes causes hormonal changes in the female body that result in ovulation and menstrual cycle disruptions. Diabetes occurs in two forms: type 1 and type 2 diabetes. Both may hinder a woman's ability to conceive. It has been reported that a woman with diabetes may also experience poor egg quality, hormonal disruptions, or irregular menstrual cycles. The presence of high blood sugar in the system can affect the female uterine lining, which hinders implantation. Blood sugar levels must also be considered in attempting to conceive, because optimal blood sugar levels may increase fertility and promote pregnancy. This article will summarise research and support the implications of diabetes on fertility outcomes and possible treatment options for women who want to achieve pregnancy with diabetes.
The presence of high blood sugar affects reproduction by altering reproductive hormones. Increased blood sugar levels affect the function of the hormones estrogen, progesterone, and insulin, which are necessary for regular periods and ovulation. In women with diabetes, insulin resistance develops, and more insulin is produced. These reproductive hormones are associated with the ovary, thereby contributing to hormonal disorders in the ovaries. These hormonal imbalances will ultimately affect the body’s ability to release mature eggs, which hinders conception. Uncontrolled diabetes can produce irregular periods due to the disruption of progesterone and estrogen hormone levels in women. This delays ovulation or prevents it altogether, thereby reducing the chances of conception. Egg quality also becomes poor in women with diabetes, affecting fertilisation.
Women with diabetes experience the following fertility issues:
Irregular periods occur due to insulin resistance and hormonal imbalance. High blood sugar levels can affect progesterone and estrogen levels, leading to irregular menstrual cycles.
Women with type 2 diabetes often suffer from polycystic ovarian disease (PCOD) due to insulin resistance. It is the most common cause of infertility in women with diabetes due to irregular ovulation and disturbed hormone levels.
Ovarian follicles do not grow properly due to high blood sugar levels. The ovaries do not release a mature egg due to abnormal follicle development, leading to anovulation (lack of ovulation).
High blood glucose can also damage ovarian cells, leading to poor-quality eggs. Fertilisation becomes difficult due to poor egg quality, and also reduces the chance of forming a healthy embryo.
Women with diabetes also experience reduced libido and vaginal dryness, which also affects sexual functions. This affects the mental health of a woman, causing stress, which also contributes to infertility.
Women with diabetes are at a higher risk for miscarriage due to certain metabolic complications, hormonal systems, and various health issues that can have an impact on the early pregnancy period.
Women with diabetes will typically have relatively high insulin levels from their insulin sensitivity, which may alter their reproductive hormones. Increased insulin stimulates the ovaries to produce more male hormones, creating an imbalance. High male hormone levels do not allow for nutrient development of the egg, creating a disturbance in the woman's normal menstrual cycle and ovulation.
The imbalance of estrogen and progesterone also affects the preparation of the endometrium for implantation. This affects the fertility and does not allow conception. It is difficult to identify the ovulation time due to a disturbed menstrual cycle, making it difficult to conceive.
Women with diabetes can choose assisted reproductive treatment to get pregnant. In vitro fertilisation (IVF) is the best option for women with diabetes who find it difficult to conceive due to hormonal imbalance, ovulation problems, or poor egg quality. IVF effectively takes the egg directly from the ovaries, bypassing a woman's ovulatory cycle, enabling the process to occur efficiently. An additional option is called intracytoplasmic sperm injection or ICSI, which transpires when the eggs are fertilised directly with the sperm through an injection technique. Women with diabetes should consult with a fertility specialist because it is important to be in control of their blood sugar and to balance hormones for healthy maturation of the egg, as well as creating a lining inside the uterus to allow for the suitable implantation.
It is important to manage diabetes to improve fertility. Women should maintain stable blood sugar levels by making lifestyle and diet changes and taking medications. Women should eat a healthy, balanced diet to help regulate blood sugar levels. Regular exercise also helps to control glucose levels and improve reproductive health. Weight management is important to improve fertility and pregnancy outcomes. Yoga, deep breathing, and meditation help manage stress, which balances hormone levels. Ensure you take your medications on time because blood glucose levels should be well-controlled before planning pregnancy.
Diabetic women have to face many challenges during pregnancy. Close monitoring throughout pregnancy is essential for successful outcomes. Poorly managed blood glucose levels increase the risk of gestational diabetes and high blood pressure in women. Uncontrolled blood glucose levels are not safe for the developing baby as well. It raises the likelihood of congenital complications in the infant. Women with diabetes are also at risk for low-birth-weight infants, premature deliveries, as well as low levels of amniotic fluid, which can complicate an otherwise healthy pregnancy.
Diet plays an important role in controlling blood glucose levels. Women with diabetes must eat a well-balanced diet including low glycaemic foods such as lean proteins, legumes, whole grains, and green leafy vegetables to control blood sugar levels. Eat small, frequent meals to prevent a sudden rise or drop in blood glucose levels. Women should consider limits on fried foods, processed sugars, refined carbohydrates, and packaged foods that influence insulin resistance. Proper sleep and hydration help to improve metabolic health.
It is essential that women stay physically active to improve insulin resistance and reproductive functioning with diabetes. Additional lifestyle changes can improve fertility in women with diabetes, such as weight management, tobacco cessation, alcohol cessation, and limiting caffeine consumption.
It is challenging for women with diabetes to conceive. Such women often suffer from anxiety as they have to manage a chronic condition along with fertility problems. Stress further increases infertility as high stress causes hormonal imbalance and can affect the IVF success rate. Women with diabetes can join support groups, schedule counselling appointments, and engage in mindful activities to relax and feel stable mentally.
Diabetes is a long-term health problem that impacts various organ systems, including the reproductive system in women. These women can have difficulty conceiving due to fertility problems. However, controlling blood glucose levels with diet and lifestyle modifications, as well as medications as required, can improve fertility potential and have a successful pregnancy outcome.
Stress interferes with the fertility hormones in women with diabetes and can lead to irregular menstrual cycles and also interfere with ovulation.
Diabetic women can improve fertility by changing lifestyle habits, diet, exercising, and maintaining blood glucose levels.
Yes, some women with diabetes can conceive naturally with controlled blood glucose levels, healthy lifestyle modifications, and nutritious diet options.
Diabetic women who plan to get pregnant should schedule an appointment with an endocrinologist and a gynaecologist who can help to make a tailored treatment plan for managing blood glucose levels for achieving pregnancy and maintaining it.
Yes, diabetic mothers can breastfeed their children, as it is the best food for a baby, and a mother’s milk reduces the risk of type 2 diabetes later in life.