Pregnancy Success Rate in IVF

Introduction

Infertile couples like Gaurav Sharma and Himali Agarwal (name changed to protect the innocent) often ask is IVF possible after menopause? Can IVF get you pregnant even after complications in your last pregnancy? Is IVF possible after tubal ligation? Is IVF possible with low AMH? Is IVF possible with low AMH? Is IVF possible without fallopian tubes? Is IVF possible with PCOS? Is IVF possible with low sperm count? success rate for IVF, Yes, IVF hai to Mumkin hai (It is possible with IVF for you to have a baby) says Dr. Ajay Murdia Chairman, Indira IVF Group (IUI, IVF, ICSI, FERTILITY, INFERTILITY) having extensive experience of more than four decades delivering happiness to 100,000+ families from across the globe. The cause for celebration for the infertile couples started in the year 1978 when Louise Brown the first child was born after her mother successfully received IVF treatment. Brown was born because of this of natural-cycle IVF, where no stimulation was made. The particular procedure took place at Dr. Kershaw’s Cottage Clinic (now Dr. Kershaw’s Hospice) in Royton, Oldham, Great Britain. Robert G. Edwards was awarded the Nobel Award in Physiology or Medication in 2010. The physiologist co-developed the treatment collectively with Patrick Steptoe and embryologist Jean Purdy, but the latter two weren’t eligible for consideration as they’d died and the Nobel Prize is not awarded posthumously.

Moreton, Cole (14 January 2007). “World’s first test-tube baby Louise Brown has a child of her own”. London: Independent. Retrieved 21 May 2010. The 28-year-old, whose pioneering conception by in-vitro fertilisation made her famous around the world. The fertility specialists Patrick Steptoe and Bob Edwards became the first to successfully carry out IVF by extracting an egg, impregnating it with sperm and planting the resulting embryo back into the mother

The 2nd successful birth of a new test tube baby happened in India just 67 days after Louise Brown was born. The girl, named Durga conceived in vitro by using a method developed independently by Doctor Subhash Mukhopadhyay, a new physician, and researcher coming from Kolkata, India.

However, this particular method of getting pregnant brought a glimmer of hope for all those infertile couples like Gaurav Sharma and Himali Agarwal who wish to have their child. IVF made it possible a feat which was considered impossible before the above success explained Dr. Shilpa Gulati from the Indira IVF clinic in Amritsar while addressing the particular concerns of infertile couples in a seminar at the Indira IVF center in Amritsar.

Together with egg donation and IVF, women who are past their reproductive years, have got infertile male partners, possess idiopathic female-fertility issues, or perhaps have reached menopause, could still become pregnant. Adriana Iliescu held the document as the oldest lady to give birth using IVF and donated egg when she gave birth in 2004 when Justin was 66, a new record passed in 2006. Following the IVF treatment, several couples get pregnant with no fertility treatments. In 2018 it was estimated that 8000000 children were born around the world using IVF and some other assisted reproduction techniques informed the best IVF specialist in Amritsar Dr. Shilpa Gulati from the Indira IVF hospital in Amritsar.

IVF could be employed to cure female infertility when it is due to issues with the fallopian tubes, making in vivo fertilization difficult. It could also assist in male infertility, in those cases that result in a defect in semen quality; in such circumstances, intracytoplasmic sperm injection (ICSI) can be utilized, where a semen cell is injected straight into the ovum. It is employed when sperm has difficulty penetrating the egg. In these cases typically the partner’s or a donor’s sperm can be used. ICSI will be used when semen numbers are incredibly low. When it is indicated, that the use of ICSI has been found to improve the Pregnancy success rates of IVF assured Dr. Shilpa Gulati from the Indira IVF treatment center in Amritsar.

In accordance with UK’s NICE guidelines, IVF cure is suitable for unexplained infertility for women who have not conceived after a couple of years of regular unprotected sex intercourse. In ladies with anovulation, it can be a great alternative after 7: 12 attempted cycles regarding ovulation induction, since the latter is expensive in addition to more an easy task to control reasoned Dr. Shilpa Gulati from the Indira IVF and IUI Clinic in Amritsar.

What is the success rate of IVF?
The success rates of IVF are usually the percentage of most IVF procedures that cause a beneficial outcome. Depending on the kind of calculation used, this specific outcome might represent the number of confirmed pregnancies, known as the pregnancy success rate in IVF, or the number of live births, called the live birth rate. Typically the success rate depends upon various factors like maternal age, cause of infertility, embryo status, reproductive system, and lifestyle aspects.

Maternal age: Young candidates of IVF are usually more likely to get pregnant. Women over the age of forty-one are more likely to get pregnant using a donor egg.
Reproductive history: Women who were previously pregnant are more successful with IVF treatments than all those who have never been pregnant.
Due to advances in reproductive technologies, IVF success rates are usually substantially higher today as compared to what they were just a couple of years ago answered Dr. Shilpa Gulati from the Indira IVF and test tube baby clinic in Amritsar.

What is a live birth rate in IVF?
The live birth rate in IVF will be the percentage of all IVF cycles that result in a live birth. This type of rate does not include miscarriage or stillbirth; multiple-order births, such as twins and triplets, are usually counted as one pregnancy.

The clinics in Canada disclosed in 2006, the live birth rate of 27%. Birth rates in young patients were moderately higher, having a success rate of thirty-five. 3% for that twenty-one and more youthful, the youngest group evaluated. Success rates for older patients had been lower and reduced with age, with 37-year-olds at 27.4% in addition to no live births concerning those older than forty-eight, the oldest group evaluated. Some treatment centers exceeded these rates. However, it is impossible to figure out if that is because of superior technique or patient selection since it is feasible to artificially increase achievement rates by refusing to take the problematic patients or by steering these people into oocyte donation process (which are compiled separately). Further, pregnancy rates could be increased by the placement of several embryos at the risk of increasing the possibility for multiples.

Since not every IVF cycle which is started will result in oocyte collection or embryo transfer, information of live birth rates need to specify the particular denominator, namely IVF process started IVF retrievals, or perhaps embryo transfers. The SART summarized 2008-9 success rates for US clinics with regard to fresh embryo cycles that failed to involve donor eggs and gave live birth rates by the age of the potential mom, with a peak in 41.3% per cycle started and 47.3% per embryo transfer for IVF patients who are under 35 years of age.

IVF attempts in multiple cycles lead to elevated cumulative live birth rates. According to the demographic group, a study reported 45% to 53% for three attempts, plus 51% to 71% to 80% for six tries replied Dr. Shilpa Gulati from the Indira IVF and Surrogacy Center in Amritsar.

What is the pregnancy success rate in IVF?
The pregnancy success rate in IVF might be defined in different ways. In the United States, the pregnancy rate employed by the Society for Assisted Reproductive Technology and the Centers for Disease Control (and appearing inside the table in the Success Rates section above) is usually based on fetal heart motion observed in ultrasound examinations.

In 2006, clinics in Canada reported an average pregnancy rate of 35%. A new French study estimated that 66% of patients beginning IVF treatment would finally do well in having a baby (40% during the IVF treatment and 26% after IVF discontinuation). The success of having a baby following IVF discontinuation was primarily due to adoption (46%) or unplanned pregnancy (42%) explained Doctor Shilpa Gulati from the Indira IVF and Surrogacy Center in Amritsar.

Predictors of success
The primary potential factors that affect pregnancy (and live birth) rates in IVF are mother’s age, duration of infecundity or subfertility, bFSH in addition to some oocytes, almost all reflecting ovarian function. Optimal woman’s age group is 23–39 years in moments of treatment.

The triple-line endometrium is related to better IVF results.

Biomarkers that influence the pregnancy probability of IVF include:

Antral follicle depends, with a higher count offering increased success rates.
Anti-Müllerian hormone levels, having increased levels indicating an increased likelihood of pregnancy, and also live birth after IVF, even right after adjusting for age informed Dr. Shilpa Gulati from your Indira IVF and test tube baby clinic in Amritsar.

Aspects of sperm quality
Stage of DNA fragmentation as measured, e.g., by Comet assay, advanced maternal age in addition to semen quality.

Women along with ovary-specific FMR1 genotypes which include low have drastically reduced pregnancy chances in IVF.

PE on the day regarding induction of final maturation is usually associated with lower maternity rates in IVF process in women undergoing ovarian stimulation using GnRH analogs and gonadotrophins. At this time, in contrast to a progesterone level below 0.8 ng/ml, a level between 0.8 and 1 ng/ml confers a probabilities ratio of pregnancy of approximately 0.8, and also a scale between 1.2 as well as 3.0 ng/ml confers a probability ratio of pregnancy of between 0.6 and 0.7. However, progesterone elevation does not seem to consult a decreased potential for pregnancy in frozen-thawed cycles and process with egg donation.

It is the qualities of cells from the cumulus oophorus and the membrane granulosa that are easily aspirated during oocyte retrieval. These cells are usually closely associated with the oocyte and share the same micro environment, as well as the rate of expression of specific genes in such cells, is associated with increased or low pregnancy rate.

An EMT <7 mm reduces the pregnancy rate by an odds ratio of around 0.4 when compared with an EMT of over seven millimeters. However, such reduced thickness rarely occurs, and any regular usage of this particular parameter is regarded as not justified explained Dr. Shilpa Gulati from the Indira IVF and IUI Clinic in Amritsar.

Other determinants of outcome of IVF include:
Tobacco smoking reduces the chances of IVF creating a live birth by 34% and increases the risk of an IVF pregnancy miscarrying by thirty percent.
A BMI of over 27 causes a 33% reduction in chance to get a live birth after the first cycle of IVF when compared to individuals with a BMI between 20 and 27. Also, pregnant ladies who are obese have got higher rates of losing the unborn baby, gestational diabetes, higher blood pressure, thromboembolism and problems during delivery, as well as leading to an elevated risk of congenital fetal abnormality. Ideal body mass index is 19–30.
Salpingectomy before IVF treatment enhances chances for ladies with hydrosalpinges.
Success with a previous pregnancy and live birth increases chances.
Low alcohol/caffeine consumption increases success rate.
The number of embryos transmitted in the treatment cycle clarified Dr. Shilpa Gulati is coming from the Indira IVF treatment center in Amritsar.
Embryo quality
Some studies likewise advise the autoimmune condition could also play a part in reducing IVF success rates by impending with proper implantation of the embryo after transfer.

Aspirin is sometimes prescribed by doctors to women for the objective of increasing the possibilities of conception by IVF;however since 2016 presently there was no evidence to show that it will be safe and effective.

A 2013 evaluation and meta-analysis of randomized handled trials of acupuncture therapy as an adjuvant remedy in IVF found no overall benefit. Also, concluded that an apparent advantage detected within a subset of published trials where the particular control group (those not using acupuncture) experienced lower than average rate of pregnancy requires more study, due to the likelihood of publication and other factors.

A Cochrane review emerged to endometrial injury performed within the month ahead of ovarian induction seemed to improve both the live birth rate and clinical pregnancy rate in IVF compared to no endometrial injury. There is no evidence of a distinction between groups in miscarriage, multiple pregnancies or bleeding rates. Proof suggested that endometrial injury on the day of oocyte collection was associated with the lower live birth or ongoing pregnancy rate.

For ladies, consumption of antioxidants (such as N-acetyl-cysteine, melatonin, vitamin C, vitamin A, vitamin E, myo-inositol, folic acid,zinc or selenium) has not been associated with a substantially increased live birth rate or medical pregnancy rate in IVF according to Cochrane reviews. The evaluation found that oral antioxidants given to men in couples with a male element or unexplained subfertility might improve live birth rates, but more evidence is usually needed.

A Cochrane review in 2015 arrived to the result there is no evidence discovered in connection with the effect of pre-conception way of life advice on the chance of a live birth result concluded Doctor Shilpa Gulati from the Indira IVF clinic in Amritsar.

Summary
IVF has given a fair chance to millions of couple since the first child from IVF was born. However IVF success is depended on case to case basis. Hence it is advisable for those looking to complete their family to consult a reputed IVF clinic like Indira IVF and then proceed accordingly.